Indian - Scientist | 1970 -
I'm human, we all are - all doctors are - and grieving is a natural part of medicine. As a doctor, grieving is a natural part of medicine. If you deny that, again, you'd get into this trap of curing and victory. I think grief is very important.
Siddhartha Mukherjee
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The trick to my writing, it turned out, was doing so exclusively in bed. The minute I even dared to discipline myself and write at the desk, I produced mounds of nonsense. Yet, sitting in bed, I wrote easily, effortlessly, fluidly. I became the master of perfect indiscipline.
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I once set myself a deadline: half a chapter a week, 20 minutes a day. The thought froze me instantly, like literary Botox. I returned to my non-schedule: sleeping, writing 20 minutes, and then back to sleep. Breakfast in bed, with juice congealing on the sill: pages and pages began to pour out again.
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Mary Lasker was an entrepreneur; she was a socialite. She was kind of a legendary networker. She became interested in saying, 'Well, you know, if these diseases don't have political support we'll never conquer them.' And she made, really, cancer her special cause.
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I think you would have to be a nihilist to say that we are not making progress on cancer, just like you'd have to be hubristically optimistic to say that we have conquered cancer.
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Each of us knows a few or several young people whose lives have been devastated by cancer. I don't mean to be nihilistic about it, but it is very much an active killer of people now.
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We may have to learn to live with cancer rather than die of it. It means a big change in our mindset and how we do research. We haven't quite reached there yet.
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There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients, or providing patients with psychic solace or pain relief. So, in fact, the gamut of medical intervention is enormous.
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Nearly every one of the genes that turns out to be a key player in cancer has a vital role in the normal physiology of an organism. The genes that enable our brains and blood cells to develop are implicated in cancer.
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Because I work on leukemia, the image of cancer I carry in my mind is that of blood. I imagine that doctors who work on breast cancer or pancreatic cancer have very different visualizations.
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If you take 100 breast-cancer samples, 100 types of cancer have 100 different hallmarks of mutated genes. You could be nihilistic and say, 'Oh, God, we'll never be able to tackle this!' But there are deep, systematic, organizational principles at work in all that diversity.
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A strong intuition is much more powerful than a weal test. Normals teach us rules; outliers teach us laws. For every perfect medical experiment, there is a perfect human bias.
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