American - Scientist | February 22, 1954 -
If you can slow the biological process of aging, even a minor slowdown in the rate at which we age yields improvements in virtually every condition of frailty and disability and mortality that we see at later ages.
S. Jay Olshansky
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We're not trying to make us live forever; we're not trying to even make us live significantly longer. What we're trying to do is extend the period of healthy life.
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Researchers have been looking for biomarkers of age for a long time and have failed. People sell tests out there to measure your biological age, and none of them work. There's no evidence that you can measure biological age with any reliability.
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Just because someone looks old doesn't mean he or she is. The skin of some people who spend a lot of time outdoors seems to age very rapidly. Someone can look 80 or 90 and only be 40 to 50.
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You can open up a centenarian's brain, and you'll see some areas that look like that of a 50-year-old or of a 110-year-old. You can have variation in the basic process of aging, called senescence, in different parts of the same body.
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Exercise is roughly equivalent to an oil lube and a filter for a car. You don't have to do it, but when you do, it makes the car run a lot better.
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The reason we have cancer and heart disease is the same reason you can't get rid of the wear and tear on your tires on your car: as soon as you use them, you are wearing them away. You can't make eternal tires, and it's the same with the human body.
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When you hit your 40s, you begin to take notice of the effects of aging because people that you know begin to die of heart attacks and tumors, so we take notice of the effects of aging.
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Reducing caloric intake is the only proven method of extending life. If caloric intake is reduced to 20 percent below maintenance, you can extend your lifespan considerably.
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The field of ageing research is full of characters. We have hucksters claiming that cures for ageing can be bought and sold; prophetic seers, their hands extended for money, warning that immortality is nigh; and would-be Nobelists working methodically in laboratories in search of a pill to slow ageing.
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Someone will eventually succeed in this hunt for a longevity pill, and when they do, one of the greatest advances in the history of medicine will have been achieved.
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I have little doubt that gerontologists will eventually find a way to avoid, or more likely, delay, the unpleasantries of extended life.
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