British - Scientist | March 27, 1942 - March 6, 2018
If we understand the worm, we understand life.
John Sulston
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I don't want a few extra weeks of life at enormous cost, for example, when it comes to the end.
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It is very clear that the present system of innovation for medicines is very inefficient and really somewhat corrupt. It benefits shareholders over patients; it produces for the rich markets and not for the poor and does not produce for minority diseases.
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The strong evidence is that we're running out of space. We're collectively affecting the world's climate. This is due to the still-growing human population and our increase in consumption.
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We can choose to address the twin issues of population and consumption to rebalance the use of resources to a more egalitarian pattern of consumption.
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The only thing I have retained from my upbringing - I did not retain the religious element - is the idea that you do not do things for money.
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I believe our basic information, our 'software', should be free and open for everyone to play with, to compete with, to try and make products from. I do not believe it should be under the control of one person.
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In science, as in business, there must be structures that ensure the well endowed do not use their position to block competition.
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The currencies of science are discoveries and ideas; the rewards are the excitement of going where nobody has been before and, if one is inclined to such things, the kudos of peer acclaim, plus funds to do more research.
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When results are shared freely amongst the biological community, as has been done for the worm and the Human Genome Projects, specialist scientists can move much more rapidly towards their goals.
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Our work on C. elegans emphasized the benefits of sharing large amounts of information. We took a global approach to discover the mechanisms that led to the development of the worm.
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We knew that all the protein-coding bits of genes do is to produce protein - they have to have instructions to turn them on and off. Those sequences lie well outside the protein-coding sequences, sometimes thousands, tens of thousands of bases away.
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